Von D appeared in two seasons of Miami Ink, the reality TV show taped at 305 Ink in Miami for the cable network TLC. She was offered the place on the show after fellow artist Darren Brass broke his elbow, preventing him from tattooing. While on the show, she had a falling out with Ami James, which led to her decision to leave the shop and the show.

She subsequently acquired her own TLC series, LA Ink, which chronicled her work at her tattoo shop, High Voltage Tattoo, in Hollywood, California. On the show, she broke the Guinness World Record of most tattoos given by a single person in 24 hours, with a total of 400. Accomplished in December 2007, it involved a Von D-designed logo for the city of Los Angeles, with proceeds going to the children’s-blindness charity Vitamin Angels. LA Ink ran four seasons, ending September 15, 2011; TLC announced the cancellation on August 18, 2011. Von D has publicly said that the cancellation was because she chose not to continue doing the show.